Ciprofloxacin is one of a new generation of fluorinated quinolones structurally related to
nalidixic acid. The primary mechanism of action of ciprofloxacin is inhibition of bacterial DNA …

Ciprofloxacin, considered a benchmark when comparing new fluoroquinolones, shares with
these agents a common mechanism of action: inhibition of DNA gyrase. While ciprofloxacin …

Objectives: To outline the concepts involved in optimizing antibacterial dosing in critically ill
patients with acute renal failure undergoing continuous renal replacement therapy (CRRT) …

Continuous renal replacement therapy (CRRT), particularly continuous venovenous
haemofiltration (CVVH) and continuous venovenous haemodiafiltration (CVVHDF), are …

Compared with nalidixic acid, ciprofloxacin is representative of a newer, more potent class of
quinolones, termed the fluoroquinolones. It is available in both oral and parenteral dosage …

Prediction accuracy of pharmacokinetic parameters is often assessed using prediction fold
error, ie, being within 2-, 3-, or n-fold of observed values. However, published studies …

This study identified the routes of elimination of ciprofloxacin in two groups of five subjects
each: one of healthy volunteers; the other of patients with severe renal failure having a mean …

Background: Appropriate antibacterial therapy is important to maximize patient survival in
sepsis. Acute renal failure complicates optimal antibiotic administration. Methods: MEDLINE …

Rapid emergence of resistance against antibacterial s emphasizes the need for the
development of novel and/or more potent antibacterials. Tigecycline is the first …

Ciprofloxacin for inhalation (CFI) is an aqueous sustained release formulation of
ciprofloxacin in development to manage respiratory infections. The liposomal formulation …