N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …

Heterochronic parabiosis consists of surgically connecting the circulatory systems of a
young and an old animal. This technique serves as a model to study circulating factors that …

Increased mitochondrial damage plays a critical role in many neurodegeneration-related
diseases such as Parkinson's disease (PD) and Down syndrome (DS). Thus, enhancement …

The largest risk factor for dementia is age. Heterochronic blood exchange studies have
uncovered age-related blood factors that demonstrate 'pro-aging'or 'pro-youthful'effects on …

Background Diabetic peripheral neuropathy (DPN) is one of the most common
complications of diabetes and the main cause of non-traumatic amputation, with no ideal …

Neurological disorders are the primary cause of human disability and mortality globally,
however, current medications slightly alleviate some symptoms of degenerative diseases …

Background The results of clinical trials for Alzheimer's disease (AD) patients treated with
Intravenous immunoglobulin (IVIG) revealed inconsistency in efficacy. Objective To explore …

The central nervous system (CNS) exhibits remarkable adaptability throughout life, enabled
by intricate interactions between neurons and glial cells, in particular, oligodendrocytes …

Abstract Alzheimer's disease (AD), the leading cause of dementia, is characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition …