Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

P2X receptors are a distinct family of ligand-gated ion channels activated by extracellular
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported …

Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and
neurotransmitter known to activate purinergic P2X receptors. Information has been …

Anedoctal evidence accumulated over almost 20 years has shown that many different cell
types are killed by sustained exposure to high concentrations of extracellular ATP. The …

Adenosine 5′-triphosphate (ATP) and/or related nucleotides act at both ionotrophic (P2X)
and metabotropic (P2Y) receptors. P2X receptors subunits (P2X1—P2X7) form ligand-gated …