Hedgehog/GLI signaling pathway: transduction, regulation, and implications for disease

AN Sigafoos, BD Paradise, ME Fernandez-Zapico - Cancers, 2021 - mdpi.com
Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

Hedgehog signaling and truncated GLI1 in cancer

D Doheny, SG Manore, GL Wong, HW Lo - Cells, 2020 - mdpi.com
The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Gli proteins in development and disease

C Hui, S Angers - Annual review of cell and developmental …, 2011 - annualreviews.org
Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 Å

NP Pavletich, CO Pabo - Science, 1991 - science.org
The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene
expression. The crystal structure of a complex containing the three zinc fingers from Zif268 …

Identification of FAP locus genes from chromosome 5q21

KW Kinzler, MC Nilbert, LK Su, B Vogelstein, TM Bryan… - Science, 1991 - science.org
Recent studies suggest that one or more genes on chromosome 5q21 are important for the
development of colorectal cancers, particularly those associated with familial adenomatous …

Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome

RL Johnson, AL Rothman, J Xie, LV Goodrich, JW Bare… - Science, 1996 - science.org
The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …

Amplification of a gene encoding a p53-associated protein in human sarcomas

JD Oliner, KW Kinzler, PS Meltzer, DL George… - Nature, 1992 - nature.com
DESPITE extensive data linking mutations in the p53 gene to human tumorigenesis1, little is
known about the cellular regulators and mediators of p53 function. MDM2 is a strong …

Gli proteins: regulation in development and cancer

P Niewiadomski, SM Niedziółka, Ł Markiewicz… - Cells, 2019 - mdpi.com
Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

B Wang, JF Fallon, PA Beachy - Cell, 2000 - cell.com
Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In
Drosophila, Ci action as transcriptional repressor or activator is contingent upon Hedgehog …

The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator

J Feng, C Bi, BS Clark, R Mady, P Shah… - Genes & …, 2006 - genesdev.cshlp.org
The identification of ultraconserved noncoding sequences in vertebrates has been
associated with developmental regulators and DNA-binding proteins. One of the first of …