Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

▪ Abstract The transcription factor NF-κB has attracted widespread attention among
researchers in many fields based on the following: its unusual and rapid regulation, the wide …

▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an
exciting and active area of study. The involvement of NF-κB in the expression of numerous …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

TRAF6 is a signal transducer in the NF-κB pathway that activates IκB kinase (IKK) in
response to proinflammatory cytokines. We have purified a heterodimeric protein complex …

Tumor necrosis factor α (TNF-α) binding to the TNF receptor (TNFR) potentially initiates
apoptosis and activates the transcription factor nuclear factor kappa B (NF-κB), which …

Mantle cell lymphoma (MCL) is an aggressive malignancy that is characterized by poor
prognosis. Large-scale pharmacological profiling across more than 100 hematological cell …

Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which
inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out …

Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and
molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the …