Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a fatal malignancy
known as adult T-cell leukemia (ATL). One way to address the pathology of the disease lies …

Tumour necrosis factor-α (TNFα) is a multifunctional cytokine belonging to a family of ligands
with an associated family of receptor proteins. The pleiotropic actions of TNF range from …

Abbreviations: Apaf, apoptosis protease activation factor; CAD, caspase-activated DNAse;
caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; …

The papillomaviruses are small DNA viruses that encode approximately eight genes, and
require the host cell DNA replication machinery for their viral DNA replication. Thus …

The corepressors N-CoR and SMRT partner with histone deacetylases (HDACs) in diverse
repression pathways. We report here that GPS2, a protein involved in intracellular signaling …

Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune
responses and many other biological processes. Similar to phosphorylation, ubiquitylation is …

The HTLV Tax protein is crucial for viral replication and for initiating malignant
transformation leading to the development of adult T-cell leukemia. Tax has been shown to …

In searching for cellular targets of the HTLV-I oncoprotein Tax, we identified TXBP181, which
we characterized as the human homolog of yeast mitotic checkpoint MAD1 protein …

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant
of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling …

The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and
cytokine-mediated activation of the transcription factor NF-κB; however, little is known about …