Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners
Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …
Mammalian phospholipase D: Function, and therapeutics
Despite being discovered over 60 years ago, the precise role of phospholipase D (PLD) is
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis
CS Lee, IS Kim, JB Park, MN Lee, HY Lee, PG Suh… - Nature cell …, 2006 - nature.com
Dynamin is a large GTP-binding protein that mediates endocytosis by hydrolyzing GTP,,.
Previously, we reported that phospholipase D2 (PLD2) interacts with dynamin in a GTP …
Previously, we reported that phospholipase D2 (PLD2) interacts with dynamin in a GTP …
Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis
W Su, Q Chen, MA Frohman - Future oncology, 2009 - Taylor & Francis
Phospholipase D (PLD) 1 and PLD2, the classic mammalian members of the PLD
superfamily, have been linked over the past three decades to immune cell function and to …
superfamily, have been linked over the past three decades to immune cell function and to …
The phox homology (PX) domain
M Chandra, BM Collins - Protein Reviews–Purinergic Receptors: Volume …, 2019 - Springer
The phox-homology (PX) domain is a phosphoinositide-binding domain conserved in all
eukaryotes and present in 49 human proteins. Proteins containing PX domains, many of …
eukaryotes and present in 49 human proteins. Proteins containing PX domains, many of …
[HTML][HTML] Phosphatidic acid, phospholipase D and tumorigenesis
J Gomez-Cambronero - Advances in biological regulation, 2014 - Elsevier
Phospholipase D (PLD) is a membrane protein with a double role: maintenance of the
structural integrity of cellular or intracellular membranes and involvement in cell signaling …
structural integrity of cellular or intracellular membranes and involvement in cell signaling …
Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of …
Cancer cells are characterized by increased production of reactive oxygen species (ROS)
and an altered redox environment as compared to normal cells. Continuous accumulation of …
and an altered redox environment as compared to normal cells. Continuous accumulation of …
Molecular structure of phospholipase D and regulatory mechanisms of its activity in plant and animal cells
YS Kolesnikov, KP Nokhrina, SV Kretynin… - Biochemistry …, 2012 - Springer
Phospholipase D (PLD) catalyzes hydrolysis of phospholipids with production of
phosphatidic acid, which often acts as secondary messenger of transduction of intracellular …
phosphatidic acid, which often acts as secondary messenger of transduction of intracellular …
Protein kinase Cζ abrogates the proapoptotic function of Bax through phosphorylation
M Xin, F Gao, WS May, T Flagg, X Deng - Journal of Biological Chemistry, 2007 - ASBMB
Protein kinase Cζ (PKCζ) is an atypical PKC isoform that plays an important role in
supporting cell survival but the mechanism (s) involved is not fully understood. Bax is a …
supporting cell survival but the mechanism (s) involved is not fully understood. Bax is a …
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase
H Choi, TL Leto, L Hunyady, KJ Catt, YS Bae… - Journal of Biological …, 2008 - ASBMB
The mechanism of angiotensin II (Ang II)-induced superoxide production was investigated
with HEK293 or Chinese hamster ovary cells reconstituted with the angiotensin type 1 …
with HEK293 or Chinese hamster ovary cells reconstituted with the angiotensin type 1 …