To date, preclinical data has demonstrated evidence to suggest promising potential for
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …

Sigma1 (also known as sigma-1 receptor, Sig1R, σ1 receptor) is a unique pharmacologically
regulated integral membrane chaperone or scaffolding protein. The majority of publications …

The novel sulfate-bridged binuclear copper (II) complex namely [Cu2 (μ3-SO4) 2 (C4H6N2)
4](1) was obtained from the hydrothermal reaction of 2-methylimidazole (hereafter …

This study investigated Allium subhirsutum L.(AS) anticancer and antioxidant effects and
inhibition of tumor angiogenesis in a murine model of skeletal metastases due to inoculation …

Background The low extracellular pH (pH e) of tumors resulting from glycolytic metabolism is
a stress factor for the cells independent from concomitant hypoxia. The aim of the study was …

Rationale: Pain and depression, which tend to occur simultaneously and share some
common neural circuits and neurotransmitters, are highly prevalent complication in patients …

Background Cancer pain is a pervasive clinical symptom impairing life quality. Vascular
endothelial growth factor A has been well studied in tumor angiogenesis and is recognized …

Metal ions are the center of an important class of therapeutics, ie metallodrugs for their
unique coordination geometries and redox states. Many cellular functions depend on the …

Background Bone cancer pain (BCP) severely compromises the quality of life, while current
treatments are still unsatisfactory. Here, we tested the antinociceptive effects of triptolide …

Breast carcinoma causes severe pain, which decreases the quality of life of patients. Current
treatments produce adverse effects and have limited efficacy. Transient potential receptor …