Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood
vessels, lymphatics and nerves, making its repair a big challenge. Transforming growth …

The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …

Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play
essential roles in nearly every aspect of cartilage formation and maintenance. However, the …

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation,
migration, differentiation, and survival of many different cell types. It influences such diverse …

Mesenchymal stromal/stem cells (MSCs) are a population of stromal cells present in the
bone marrow and most connective tissues, capable of differentiation into mesenchymal …

Purpose: This study compared two methods of preparing platelet-rich plasma (PRP) gel and
the levels of PDGF and TGFβ in each preparation. Materials and Methods: Platelet-rich …

Endochondral ossification begins from the condensation and differentiation of mesenchymal
cells into cartilage. The cartilage then goes through a program of cell proliferation …

The multilineage differentiation potential of adult tissue-derived mesenchymal progenitor
cells (MPCs), such as those from bone marrow and trabecular bone, makes them a useful …

The transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling
pathways play a pivotal role in bone development and skeletal health. More than 30 different …

Novel approaches to treat osteoarthritis are required and progress in understanding the
biology of cartilage disorders has led to the use of genes whose products stimulate cartilage …