[HTML][HTML] PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action
M Hernandez-Quiles, MF Broekema… - Frontiers in …, 2021 - frontiersin.org
The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …
is one of the most extensively studied ligand-inducible transcription factors. Since its …
Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products
Obesity is recognized as a severe threat to overall human health and is associated with type
2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal …
2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal …
Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules
D Moseti, A Regassa, WK Kim - International journal of molecular …, 2016 - mdpi.com
Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …
Super-enhancers in the control of cell identity and disease
D Hnisz, BJ Abraham, TI Lee, A Lau, V Saint-André… - Cell, 2013 - cell.com
Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …
genes that define cell identity. Improved understanding of the roles that super-enhancers …
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …
Transcriptional and epigenomic regulation of adipogenesis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
[HTML][HTML] Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration
JE Heredia, L Mukundan, FM Chen, AA Mueller… - Cell, 2013 - cell.com
In vertebrates, activation of innate immunity is an early response to injury, implicating it in the
regenerative process. However, the mechanisms by which innate signals might regulate …
regenerative process. However, the mechanisms by which innate signals might regulate …
Adipocyte and adipogenesis
Adipocytes are the main constituent of adipose tissue and are considered to be a corner
stone in the homeostatic control of whole body metabolism. Their primary function is to …
stone in the homeostatic control of whole body metabolism. Their primary function is to …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
Review of signaling pathways governing MSC osteogenic and adipogenic differentiation
AW James - Scientifica, 2013 - Wiley Online Library
Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …