Oxidative stress: pathogenetic role in diabetes mellitus and its complications and therapeutic approaches to correction

MA Darenskaya, LI Kolesnikova… - Bulletin of experimental …, 2021 - Springer
The review presents modern views about the role of oxidative stress reactions in the
pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the …

Oxidative stress in type 2 diabetes: impacts from pathogenesis to lifestyle modifications

A Caturano, M D'Angelo, A Mormone, V Russo… - Current Issues in …, 2023 - mdpi.com
Oxidative stress is a critical factor in the pathogenesis and progression of diabetes and its
associated complications. The imbalance between reactive oxygen species (ROS) …

Diabetes mellitus and its metabolic complications: the role of adipose tissues

L Dilworth, A Facey, F Omoruyi - International journal of molecular …, 2021 - mdpi.com
Many approaches have been used in the effective management of type 2 diabetes mellitus.
A recent paradigm shift has focused on the role of adipose tissues in the development and …

Insulin resistance and cardiovascular disease

CE Kosmas, MD Bousvarou… - Journal of …, 2023 - journals.sagepub.com
Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …

Role of oxidative stress in diabetic cardiomyopathy

B De Geest, M Mishra - Antioxidants, 2022 - mdpi.com
Type 2 diabetes is a redox disease. Oxidative stress and chronic inflammation induce a
switch of metabolic homeostatic set points, leading to glucose intolerance. Several diabetes …

Antioxidant peptides, the guardian of life from oxidative stress

Y Zhu, K Wang, X Jia, C Fu, H Yu… - Medicinal Research …, 2024 - Wiley Online Library
Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic
organisms. Under normal conditions, ROS production and elimination are in a relatively …

Understanding cellular redox homeostasis: A challenge for precision medicine

V Tretter, B Hochreiter, ML Zach, K Krenn… - International journal of …, 2021 - mdpi.com
Living organisms use a large repertoire of anabolic and catabolic reactions to maintain their
physiological body functions, many of which include oxidation and reduction of substrates …

Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia

JEBF Lima, NCS Moreira, ET Sakamoto-Hojo - Mutation Research/Genetic …, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is a complex multifactorial disease that emerges from the
combination of genetic and environmental factors, and obesity, lifestyle, and aging are the …

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

C Wang, W Yuan, A Hu, J Lin… - Molecular …, 2020 - spandidos-publications.com
Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, and
ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), a α2‑adrenergic receptor …

Oxidative stress and microvascular alterations in diabetic retinopathy: future therapies

ML Rodríguez, S Pérez, S Mena-Mollá… - Oxidative Medicine …, 2019 - Wiley Online Library
Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin.
However, patients' metabolic control is inadequate in a high percentage of them and a major …