Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Abdominal aortic aneurysm (AAA) is a potentially life-threatening disorder with a mostly
asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play …

Marfan syndrome (MFS) is a complex connective tissue disease that is primarily
characterized by cardiovascular, ocular and skeletal systems disorders. Despite its rarity …

The extracellular matrix (ECM) imparts critical mechanical and biochemical information to
cells in the lungs. Proteoglycans are essential constituents of the ECM and play a crucial …

We discovered that Cadherin-11 (CDH11) regulates collagen and elastin synthesis, both
affecting the mechanical properties and contractile function of animal tissues. Using a …

The cornea is continuously exposed to injuries, ranging from minor scratches to deep
traumas. An effective healing mechanism is crucial for the cornea to restore its structure and …

Objective The prevalence of Marfan syndrome (MFS) is estimated to be 1 in 10,000 to
15,000 individuals, but the phenotype of MFS may not be apparent and hence its diagnosis …

Abdominal aortic aneurysms (AAAs) are focal dilations of the aorta that develop from
degenerative changes in the media and adventitia of the vessel. Ruptured AAAs have a …

Background Marfan syndrome (MFS) is a systemic connective tissue disorder with life-
threatening manifestations affecting the ascending aorta. MFS is caused by dominant …