Ribosome protection proteins—“New” players in the global arms race with antibiotic-resistant pathogens
R Ero, XF Yan, YG Gao - International Journal of Molecular Sciences, 2021 - mdpi.com
Bacteria have evolved an array of mechanisms enabling them to resist the inhibitory effect of
antibiotics, a significant proportion of which target the ribosome. Indeed, resistance …
antibiotics, a significant proportion of which target the ribosome. Indeed, resistance …
Practical gram-scale synthesis of iboxamycin, a potent antibiotic candidate
JD Mason, DW Terwilliger, AR Pote… - Journal of the American …, 2021 - ACS Publications
A gram-scale synthesis of iboxamycin, an antibiotic candidate bearing a fused bicyclic
amino acid residue, is presented. A pivotal transformation in the route involves an …
amino acid residue, is presented. A pivotal transformation in the route involves an …
A practical, component-based synthetic route to methylthiolincosamine permitting facile northern-half diversification of lincosamide antibiotics
The development of a flexible, component-based synthetic route to the amino sugar
fragment of the lincosamide antibiotics is described. This route hinges on the application …
fragment of the lincosamide antibiotics is described. This route hinges on the application …
Practical Synthesis of Iboxamycin, a Potent Antibiotic Candidate, in Amounts Suitable for Studies in Animal Infection Models
J Mason, DW Terwilliger, AR Pote, AG Myers - 2021 - chemrxiv.org
A gram-scale synthesis of iboxamycin, an antibiotic candidate bearing a fused bicyclic
amino acid residue, is presented. A pivotal transformation in the route involves an …
amino acid residue, is presented. A pivotal transformation in the route involves an …