New avenues for the treatment of Huntington's disease

A Kim, K Lalonde, A Truesdell, P Gomes Welter… - International journal of …, 2021 - mdpi.com
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Molecular mechanisms and potential therapeutical targets in Huntington's disease

C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Conditional BDNF delivery from astrocytes rescues memory deficits, spine density, and synaptic properties in the 5xFAD mouse model of Alzheimer disease

B de Pins, C Cifuentes-Díaz, AT Farah… - Journal of …, 2019 - Soc Neuroscience
It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …

Nerve growth factor signaling, neuroprotection, and neural repair

MV Sofroniew, CL Howe… - Annual review of …, 2001 - annualreviews.org
▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Stem cells in the central nervous system

R McKay - Science, 1997 - science.org
In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support

SE Marsh, M Blurton-Jones - Neurochemistry international, 2017 - Elsevier
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease currently affect tens of millions of people worldwide. Unfortunately, as …

Role of brain-derived neurotrophic factor in Huntington's disease

C Zuccato, E Cattaneo - Progress in neurobiology, 2007 - Elsevier
Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …

The role of neuronal growth factors in neurodegenerative disorders of the human brain

B Connor, M Dragunow - Brain Research Reviews, 1998 - Elsevier
Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

Global stem cell research trend: Bibliometric analysis as a tool for mapping of trends from 1991 to 2006

LL Li, G Ding, N Feng, MH Wang, YS Ho - Scientometrics, 2009 - akjournals.com
In this study, we aim to evaluate the global scientific production of stem cell research for the
past 16 years and provide insights into the characteristics of the stem cell research activities …

The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue

KI Park, YD Teng, EY Snyder - Nature biotechnology, 2002 - nature.com
Hypoxic-ischemic injury is a prototype for insults characterized by extensive tissue loss.
Seeding neural stem cells (NSCs) onto a polymer scaffold that was subsequently implanted …