Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic
transformation. Although genetic alterations dominate the way cancer biologists think about …

Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

BRD4 is well known for its role in super-enhancer organization and transcription activation
of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks
targeted therapy options, and patients diagnosed with TNBC have poorer outcomes than …

Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) small-molecule inhibitors
in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we …

Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how
these cancer cells interact with each other is still largely unknown. Exosomes released by …

Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the
efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma …

As a substrate and major effector of the mammalian target of rapamycin complex 1
(mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …