Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

JI Tietz, CJ Schwalen, PS Patel, T Maxson… - Nature chemical …, 2017 - nature.com
Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products
are attractive for genome-driven discovery and re-engineering, but limitations in …

New insights into the biosynthetic logic of ribosomally synthesized and post-translationally modified peptide natural products

MA Ortega, WA Van Der Donk - Cell chemical biology, 2016 - cell.com
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large
group of structurally diverse natural products. Their biological activities and unique …

The expanding structural variety among bacteriocins from Gram-positive bacteria

JZ Acedo, S Chiorean, JC Vederas… - FEMS microbiology …, 2018 - academic.oup.com
Bacteria use various strategies to compete in an ecological niche, including the production
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …

Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches

L Ali, MU Goraya, Y Arafat, M Ajmal, JL Chen… - International journal of …, 2017 - mdpi.com
Quorum-sensing systems control major virulence determinants in Enterococcus faecalis,
which causes nosocomial infections. The E. faecalis quorum-sensing systems include …

Advances in lasso peptide discovery, biosynthesis, and function

SE Barrett, DA Mitchell - Trends in Genetics, 2024 - cell.com
Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-
translationally modified peptide (RiPP) natural products characterized by their slip knot-like …

Lasso peptides: heterologous production and potential medical application

C Cheng, ZC Hua - Frontiers in bioengineering and biotechnology, 2020 - frontiersin.org
Lasso peptides are natural products found in bacteria. They belong to a specific family of
ribosomally-synthesized and posttranslationally-modified peptides with an unusual lasso …

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme–Substrate Tolerance

Y Si, AM Kretsch, LM Daigh, MJ Burk… - Journal of the …, 2021 - ACS Publications
Lasso peptides are ribosomally synthesized and post-translationally modified peptide
(RiPP) natural products that display a unique lariat-like, threaded conformation. Owing to a …

Insights into the unique phosphorylation of the lasso peptide paeninodin

S Zhu, JD Hegemann, CD Fage, M Zimmermann… - Journal of Biological …, 2016 - ASBMB
Lasso peptides are a new class of ribosomally synthesized and post-translationally modified
peptides and thus far are only isolated from proteo-and actinobacterial sources. Typically …