DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

Multi-cellular organisms such as humans contain hundreds of cell types that share the same
genetic information (DNA sequences), and yet have different cellular traits and functions …

The UHRF protein family consists of multidomain regulatory proteins that sense modification
status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their …

Transcriptional memory allows certain genes to respond to previously experienced signals
more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates …

The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse
embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296 …

Meiosis is critical to generating oocytes and ensuring female fertility; however, the
mechanisms regulating the switch from mitotic primordial germ cells to meiotic germ cells …

ABSTRACT DNA methylation is a highly conserved epigenetic modification that plays
essential roles in mammalian gene regulation, genome stability and development. Despite …

Genome-wide DNA demethylation is a unique feature of mammalian development and
naïve pluripotent stem cells. Here, we describe a recently evolved pathway in which global …