Increasing antibiotic resistance in multidrug-resistant (MDR) Gram-negative bacteria (MDR-
GNB) presents significant health problems worldwide, since the vital available and effective …

Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …

Antibiotics are one of the greatest medical advances of the 20th century, however, they are
quickly becoming useless due to antibiotic resistance that has been augmented by poor …

Nephrotoxicity of colistin is the major factor limiting its clinical application. However, the
exact mechanism of colistin-induced nephrotoxicity is still elusive. N6-Methyladenosine …

The discovery of antibiotics has revolutionized medicine and has changed medical practice,
enabling successful fighting of infection. However, quickly after the start of the antibiotic era …

The objective of this review is to collect and present the results of relevant studies on an
international level, on the subject of colistin resistance due to mcr genes prevalence in …

Antimicrobial resistance represents a serious threat for global health, causing an
unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in …

In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of
available antibiotics are triggering a new health-care crisis. The discovery of novel and …

Gram-negative bacteria are challenging to kill with antibiotics due to their impenetrable outer
membrane containing lipopolysaccharide (LPS). The polymyxins, including colistin, are the …

Despite the increasing use of rare earth elements (REEs) and oxides (REOs) in various
technologies, the information on their ecotoxicological hazard is scarce. Here, the effects of …