The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All
three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β …

The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells.
The hypoxic-sensitive regulation of gene expression allows information about the oxygen …

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in
zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes …

The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …

Background As context is important to gene expression, so is the preprocessing of
microarray to transcriptomics. Microarray data suffers from several normalization and …

Dissolved oxygen (DO) undountedly affects fish distribution, metabolism, and evern survival.
Intensive aquaculture and environmental changes will inevitably lead to hypoxic stress for …

High-throughput technology has facilitated genome-scale analyses of transcriptomic
adjustments in response to environmental perturbations with an oxygen deprivation …

The zebrafish (D anio rerio) is a freshwater teleost of the family C yprinidae that is
established as a model organism in many research fields. Here, we define the …

Second only to the mouse and rat, the zebrafish is the most popular animal model in
biomedical research. Rapid embryonic development and transparent organogenesis give it …

BACKGROUND & AIMS: The infiltrating ductal adenocarcinoma of the pancreas is among
the most lethal of all solid malignancies, largely owing to a high frequency of early …