ABSTRACT C-terminal Binding Proteins (CtBP) 1 and 2 are oncogenic transcriptional co-
regulators overexpressed in many cancer types, with their expression level correlating to …

Gene transcription is strictly controlled by transcriptional complexes, which are assemblies
of transcription factors, transcriptional regulators, and co-regulators. Mammalian genomes …

Background The main cause of death in colorectal cancer patients is metastasis.
Accumulating evidences suggest that circRNA plays pivotal roles in cancer initiation and …

C-terminal binding protein 1 (CtBP1) and CtBP2 are transcriptional coregulators that repress
numerous cellular processes, such as apoptosis, by binding transcription factors and …

This review highlights current treatments, limitations, and pitfalls in the management of
pancreatic cancer and discusses current research in novel targets and drug development to …

Objective Aberrant activation of Wnt/β-catenin signaling contributes to the maintenance of
cancer stem cells and chemoresistance in colorectal cancer (CRC). Retinoic acid-induced 2 …

Background The C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate
(CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor and as a fission …

C-terminal binding protein 2 (CtBP2) is elevated in epithelial ovarian cancer, especially in
the aggressive and highly lethal subtype, high-grade serous ovarian cancer (HGSOC) …

Ctbp2 is a uniquely targetable oncogenic transcriptional coregulator, exhibiting
overexpression in most common solid tumors, and critical to the tumor-initiating cell (TIC) …

Abstract SESTRINs (SESN1-3) are proteins encoded by an evolutionarily conserved gene
family that plays an important role in the regulation of cell viability and metabolism in …