Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents
N Perico, M Cortinovis, F Suter… - The Lancet Infectious …, 2023 - thelancet.com
Summary COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of
symptom severity that requires varying amounts of care according to the different stages of …
symptom severity that requires varying amounts of care according to the different stages of …
Protection by metformin against severe Covid-19: An in-depth mechanistic analysis
N Wiernsperger, A Al-Salameh, B Cariou… - Diabetes & …, 2022 - Elsevier
Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19
have reported a favourable association between metformin and Covid-19-related outcomes …
have reported a favourable association between metformin and Covid-19-related outcomes …
COVID-19 and risk of acute ischemic stroke and acute lung injury in patients with type ii diabetes mellitus: the anti-inflammatory role of metformin
Background: Coronavirus disease 19 (COVID-19) is regarded as an independent risk factor
for acute ischemic stroke (AIS) due to the induction of endothelial dysfunction, coagulopathy …
for acute ischemic stroke (AIS) due to the induction of endothelial dysfunction, coagulopathy …
SARS-CoV-2 switches 'on'MAPK and NFκB signaling via the reduction of nuclear DUSP1 and DUSP5 expression
S Goel, F Saheb Sharif-Askari… - Frontiers in …, 2021 - frontiersin.org
Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many
cellular processes and are essential for immune cells function. Their activity is controlled by …
cellular processes and are essential for immune cells function. Their activity is controlled by …
[HTML][HTML] COVID-19 associated liver injury: an updated review on the mechanisms and management of risk groups
Y Shi, M Wang, L Wu, X Li, Z Liao - Liver Research, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has been associated with various liver
injury cases worldwide. To date, the prevalence, mechanism, clinical manifestations …
injury cases worldwide. To date, the prevalence, mechanism, clinical manifestations …
[HTML][HTML] Factors regulating dynamics of angiotensin-converting enzyme-2 (ACE2), the gateway of SARS-CoV-2: Epigenetic modifications and therapeutic interventions …
Abstract Angiotensin-converting enzyme-2 (ACE2) is one of the major components of the
renin-angiotensin system (RAS) and participates in the physiological functions of the …
renin-angiotensin system (RAS) and participates in the physiological functions of the …
The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7
W Chen, X Wu, J Hu, X Liu, Z Guo, J Wu… - Cardiovascular …, 2024 - Springer
Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …
Altered plasma levels of the SARS-CoV-2-related proteins ACE2 and TMPRSS2 in patients with Crohn's disease
J Sáez-Leyva, MP Lennol, C Avilés-Granados… - Scientific Reports, 2024 - nature.com
The SARS-CoV-2 coronavirus infects cells through the cellular receptor angiotensin-
converting enzyme 2 (ACE2), and the protease TMPRSS2 for the priming of viral spike …
converting enzyme 2 (ACE2), and the protease TMPRSS2 for the priming of viral spike …
Home pharmacological therapy in early COVID‐19 to prevent hospitalization and reduce mortality: time for a suitable proposal
S Pandolfi, S Chirumbolo, G Ricevuti… - Basic & Clinical …, 2022 - Wiley Online Library
The COVID‐19 pandemic is a highly dramatic concern for mankind. In Italy, the pandemic
exerted its major impact throughout the period of February to June 2020. To date, the …
exerted its major impact throughout the period of February to June 2020. To date, the …
Metformin use in relation to clinical outcomes and hyperinflammatory syndrome among COVID-19 patients with type 2 diabetes: a propensity score analysis of a …
Aim This study was conducted in order to evaluate the association between metformin use
and clinical outcomes in type 2 diabetes mellitus (T2DM) patients hospitalized with …
and clinical outcomes in type 2 diabetes mellitus (T2DM) patients hospitalized with …