Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …

Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

Mast cells (MCs) are tissue-resident immune cells that exhibit homeostatic and neuron-
associated functions. Here, we combined whole-tissue imaging and single-cell RNA …

Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset;
characterized by life-threatening airway, breathing, and/or circulatory problems; and usually …

Many consider food allergy as the" second wave" of the allergy epidemic following the" first
wave" of respiratory allergy, ie, asthma and allergic rhinitis, plaguing westernized countries …

IgE-associated food allergy affects approximately 3% of the population and has severe
effects on the daily life of patients—manifestations occur not only in the gastrointestinal tract …

Anaphylaxis is a systemic acute hypersensitivity reaction that is considered to depend on
allergen-specific immunoglobulin E (IgE) antibodies and histamine release by mast cells …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …

Food allergy is a public health issue the prevalence of which is steadily increasing. New
discoveries have contributed to the understanding of the molecular and cellular mechanisms …

Food allergy now affects 6%–8% of children in the Western world; despite this, we
understand little about why certain people become sensitized to food allergens. The …