Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐
mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial …

Equine practitioners require recommendations that support antimicrobial stewardship and
avoid generating resistance to medically important antibiotics. This review examines current …

Florfenicol is a member of the phenicol group, a broad-spectrum antibacterial agent. It has
been used for a long time in veterinary medicine, but there are some factors regarding its …

The study was to explore the rational use of danofloxacin against Mycoplasma gallisepticum
(MG) based on its clinical breakpoint (CBP) and the effect on lung microbiota. The CBP was …

The PK/PD cut-off (PK/PDCO) value of florfenicol for calf pathogens was determined for long
acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of …

These disorders are characterized by inspiratory dyspnea. The increased resistance to
airflow caused by upper airway obstructions often creates audible inspiratory noise and …

A major problem of our time is the ever-increasing resistance to antimicrobial agents in
bacterial populations. One of the most effective ways to prevent these problems is to target …

Background There is conflicting data regarding the efficacy of tulathromycin for the treatment
of foals with bronchopneumonia. Hypotheses Tulathromycin is effective for the treatment of …

Antimicrobial drug concentrations in the gastrointestinal tract likely drive antimicrobial
resistance in enteric bacteria. Our objective was to determine the concentration of ceftiofur …

An important application of time-kill curve (TKC) assays is determination of the nature of the
best PK/PD index (f AUC/MIC or f T%> MIC) and its target value for predicting clinical …