Oxidative stress and sarcomeric proteins

SF Steinberg - Circulation research, 2013 - Am Heart Assoc
Oxidative stress accompanies a wide spectrum of clinically important cardiac disorders,
including ischemia/reperfusion, diabetes mellitus, and hypertensive heart disease. Although …

Emerging importance of oxidative stress in regulating striated muscle elasticity

L Beckendorf, WA Linke - Journal of muscle research and cell motility, 2015 - Springer
The contractile function of striated muscle cells is altered by oxidative/nitrosative stress,
which can be observed under physiological conditions but also in diseases like heart failure …

[HTML][HTML] An ischemic area-targeting, peroxynitrite-responsive, biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury

J Zhang, L Liu, Z Dong, X Lu, W Hong, J Liu, X Zou… - Bioactive Materials, 2023 - Elsevier
Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo
revascularization therapy for myocardial infarction, often leading to cardiac dysfunction …

Cardiovascular disorders triggered by obstructive sleep apnea—a focus on endothelium and blood components

J Mochol, J Gawrys, D Gajecki… - International Journal of …, 2021 - mdpi.com
Obstructive sleep apnea (OSA) is known to be an independent cardiovascular risk factor.
Among arousal from sleep, increased thoracic pressure and enhanced sympathetic …

Signaling by S-nitrosylation in the heart

E Murphy, M Kohr, S Menazza, T Nguyen… - Journal of molecular and …, 2014 - Elsevier
Nitric oxide is a gaseous signaling molecule that is well-known for the Nobel prize-winning
research that defined nitric oxide as a physiological regulator of blood pressure in the …

Activation of intracellular matrix metalloproteinase-2 by reactive oxygen–nitrogen species: Consequences and therapeutic strategies in the heart

AL Jacob-Ferreira, R Schulz - Archives of biochemistry and biophysics, 2013 - Elsevier
Reactive oxygen–nitrogen species play important roles in physiological and pathological
processes in the heart. This review will focus on the activation of matrix metalloproteinases …

S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death

MJ Kohr, AM Evangelista, M Ferlito… - Journal of molecular and …, 2014 - Elsevier
Oxidative stress and membrane damage following myocardial ischemia/reperfusion injury
are important contributors to cardiomyocyte death and the loss of myocardial function. Our …

Role of peroxynitrite in the cardiovascular dysfunction of septic shock

L Liaudet, N Rosenblatt-Velin… - Current Vascular …, 2013 - ingentaconnect.com
The intense systemic inflammatory response characterizing septic shock is associated with
an increased generation of free radicals by multiple cell types in cardiovascular and non …

A change of heart: oxidative stress in governing muscle function?

M Breitkreuz, N Hamdani - Biophysical Reviews, 2015 - Springer
Redox/cysteine modification of proteins that regulate calcium cycling can affect contraction
in striated muscles. Understanding the nature of these modifications would present the …

SMYD2 glutathionylation contributes to degradation of sarcomeric proteins

DNP Munkanatta Godage, GC VanHecke… - Nature …, 2018 - nature.com
Reactive oxygen species (ROS) contribute to the etiology of multiple muscle-related
diseases. There is emerging evidence that cellular stress can lead to destabilization of …