Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of
individuals to diseases. All individuals have DNA risk variants for all common diseases, but …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …

Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …

Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …

For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …