Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …

Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …

Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the
production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin
is considered an anti‐aging agent due to its cytoprotective actions as an antioxidant. This …

The ribosome, central to protein synthesis in all cells, is a complex multicomponent
assembly with rRNA at its functional core. During the process of ribosome biogenesis …

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of
Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats …

Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …