Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a
promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated …

Background: The integrated stress response (ISR) is an evolutionarily conserved process to
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …

The endoplasmic reticulum (ER) hosts linear polypeptides and fosters natural folding of
proteins through ER-residing chaperones and enzymes. Failure of the ER to align and …

Under physiological conditions, reactive oxygen species (ROS) function as signaling
molecules that control cell function. However in pathological conditions, increased …

The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress
response, and cell growth. However, its contribution to cardiac hypertrophic growth and …

The heart manifests hypertrophic growth in response to high blood pressure, which may
decompensate and progress to heart failure under persistent stress. Metabolic remodeling is …

Objective: To investigate the exact role of GRP78 in artesunate-induced ferroptosis in KRAS
mutant pancreatic cancer cells. Methods: Artesunate-induced KRAS mutant human …

Myocardial infarction is the first cause of worldwide mortality, with an increasing incidence
also reported in developing countries. Over the past decades, preclinical research and …