This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

3-3 proteins are abundantly expressed in the brain and have been detected in the
cerebrospinal fluid of patients with different neurological disorders. Although the function of …

Abstract The 14-3-3 family of proteins mediates signal transduction by binding to
phosphoserine-containing proteins. Using phosphoserine-oriented peptide libraries to …

Abstract THE 14-3-3 family of proteins have recently been identified as regulatory elements
in intracellular signalling pathways1: 14-3-3 proteins bind to oncogene and proto-oncogene …

We have solved the high-resolution X-ray structure of 14-3-3 bound to two different
phosphoserine peptides, representing alternative substrate-binding motifs. These structures …

A BROAD range of organisms and tissues contain 14-3-3 proteins, which have been
associated with many diverse functions including critical roles in signal transduction …

Many signal transduction events are orchestrated by specific interactions of proteins
mediated through discrete phosphopeptide-binding motifs. Although several …

14‐3‐3 proteins play a role in many cellular functions: they bind to and regulate several
proteins which are critical for cell proliferation and differentiation. 14‐3‐3 proteins exist as …

Members of the highly conserved and ubiquitous 14-3-3 protein family modulate a wide
variety of cellular processes. To determine the evolutionary relationships among specific 14 …

Members of the 14-3-3 family are homo-and the heterodimeric proteins mediating interaction
between diverse components of many biological activities. The role of these proteins has …