Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year.
The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most …

Polycomb group proteins are critical to maintaining gene repression established during
Drosophila development. Part of this group forms the PRC2 complex containing Ez that …

In an inducible oncogenesis model, the miR-200 family is inhibited during CSC formation
but not transformation, and inhibition of miR-200b increases CSC formation. Interestingly …

Proliferation of pancreatic islet β cells is an important mechanism for self-renewal and for
adaptive islet expansion. Increased expression of the Ink4a/Arf locus, which encodes the …

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors
morphologically resemble embryonic kidneys with a disrupted architecture and are …

Background The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities
and its (over) expression has been linked to several human malignancies. Here, we studied …

Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to
their expression of various membrane transporter molecules (such as MDR-1), detoxifying …

Epigenetic regulation of oxidative stress is emerging as a critical mediator of diabetic
nephropathy. In diabetes, oxidative damage occurs when there is an imbalance between …