Bacteriophage (phage) T4 has served as an extraordinary model to elucidate biological
structures and mechanisms. Recent discoveries on the T4 head (capsid) structure, portal …

The genome packaging motor of bacteriophages and herpesviruses is built by two
terminase subunits, known as large (TerL) and small (TerS), both essential for viral genome …

Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter
human cells and carry out molecular repairs will have broad applications. Here, we describe …

Double-stranded DNA viruses utilise machinery, made of terminase proteins, to package
viral DNA into the capsid. For cos bacteriophage, a defined signal, recognised by small …

Highlights•Single molecule, structural and computational studies on viral dsDNA packaging
motors have illuminated the underlying mechano-chemistry of genome packaging by dsDNA …

Although the process of genome encapsidation is highly conserved in tailed bacteriophages
and eukaryotic double-stranded DNA viruses, there are two distinct packaging pathways that …

Viruses are biochemically complex structures and mainly consist of folded proteins that
contain nucleic acids. Bacteriophage T4 is one of most prominent examples, having a tail …

Bacteriophage M13 assembles its progeny particles in the inner membrane of the host. The
major component of the assembly machine is G1p and together with G11p it generates an …

In all tailed phages, the packaging of the double-stranded genome into the head by a
terminase motor complex is an essential step in virion formation. Despite extensive …

DsDNA translocation through nanoscale pores is generally accomplished by ATPase
biomotors. The discovery of the revolving dsDNA translocation mechanism, as opposed to …