Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and
are suggested to be related to cancer risk. However, epidemiologic findings have been …

Human cancers exhibit genomic instability and an increased mutation rate due to underlying
defects in DNA repair. Cancer cells are often defective in one of six major DNA repair …

The chemical nature of most of the mycotoxins makes them highly liposoluble compounds
that can be absorbed from the site of exposure such as from the gastrointestinal and …

Lung cancer is the leading cause of cancer mortality worldwide. There have been only slight
improvements in early diagnosis and survival, reflecting limited advances in screening and …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) and PARP-2 belong to a family of
enzymes that, using NAD+ as a substrate, catalyze poly (ADP-ribosyl) ation of proteins …

Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of
nicotinamide adenine dinucleotide (NAD) synthesis. Both intracellular and extracellular …

Background Polymorphisms in DNA repair genes have been associated to repair DNA
lesions, and might contribute to the individual susceptibility to develop different types of …

Abstract Background Although 40–50% of non-small cell lung cancer (NSCLC) tumors
respond to cisplatin chemotherapy, there currently is no way to prospectively identify …