The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

Organ on a chip refers to microengineered biomimetic system which reflects structural and
functional characteristics of human tissue. It involves biomaterial technology, cell biology …

Abstract Three-dimensional (3D) cell culture technologies, such as organoids, are
physiologically relevant models for basic and clinical applications. Automated microfluidics …

Microfluidic systems enable automated and highly parallelized cell culture with low volumes
and defined liquid dosing. To achieve this, systems typically integrate all functions into a …

life science, clinical diagnostics, drug development, etc. Recent years have witnessed the
emergence of innovative analytical methods with high sensitivity and spatial-temporal …

Over the decades, conventional in vitro culture systems and animal models have been used
to study physiology, nutrient or drug metabolisms including mechanical and …

Immune sentinel cells initiate immune responses to pathogens and tissue injury and are
capable of producing highly stimulus-specific responses. Insight into the mechanisms …

Microfluidics is an appealing platform for drug screening and discovery. Compared with the
conventional drug screening methods based on Petri dishes and experimental animals …

Genome-scale technologies have enabled mapping of the complex molecular networks that
govern cellular behavior. An emerging theme in the analyses of these networks is that cells …

Highlights•At least four evolutionarily conserved scenarios occur during tissue
regeneration.•Cell death plays an important role in the induction of tissue regeneration.• …