Bufadienolides, naturally found in toad venoms having steroid‐like structures, reveal
antiproliferative effects at low doses. However, their application as anticancer drugs is …

Bufadienolides are cardioactive C24 steroids with an α-pyrone ring at position C17. In the
last ten years, accumulating studies have revealed the anticancer activities of …

To enable modularization for network-based prediction, we conducted a review of known
methods conducting the various subtasks corresponding to the creation of a drug–target …

Ethnopharmacological relevance Lung cancer is the leading cause of cancer incidence and
mortality worldwide. Arenobufagin (Arg), a representative natural bufadienolide compound …

The cytotoxicity of a trivalent arsenic derivative (arsenite, AsIII) combined with arenobufagin
or gamabufotalin was evaluated in human U-87 glioblastoma cells. Synergistic cytotoxicity …

Cells have different sets of molecules for performing an array of physiological functions.
Nucleic acids have stored and carried the information throughout evolution, whereas …

Arenobufagin, an active component isolated from the traditional Chinese medicine Chan Su,
exhibits anticancer influences in several human malignancies. However, the effects and …

Affinity-based protein profiling has proven to be a powerful method in target identification of
bioactive molecules. Here, this technology was applied in two photoreactive anticancer …

In this study, toad venom (TV) and realgar were loaded into a poloxamer 188/407
(F127/F188)-based temperature-sensitive in situ gel (TISG) and encapsulated in solid lipid …

Background: Aggresomes are collections of intracellular protein aggregates. In liver cells of
patients with alcoholic hepatitis, aggresomes appear histologically as cellular inclusions …