Purpose To understand why some patients respond to immunotherapy but many do not, a
clear picture of the tumor microenvironment (TME) of head and neck squamous cell …

Preclinical data suggest that head and neck squamous cell carcinoma (HNSCC) is a
profoundly immunosuppressive disease, characterized by abnormal secretion of …

Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy
is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have …

High numbers of tissue-resident memory T (TRM) cells are associated with better clinical
outcomes in cancer patients. However, the molecular characteristics that drive their efficient …

There is increasing evidence that the spatial organization of cells within the tumor-immune
microenvironment (TiME) of solid tumors influences survival and response to therapy in …

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of
malignant tumours typically caused by alcohol and tobacco consumption, although an …

Introduction Identification of tumours harbouring an overall active immune phenotype may
help for selecting patients with advanced head and neck squamous cell carcinomas …

Natural killer (NK) cells are emerging as unique players in the immune response against
cancer; however, only limited data are available on tumor infiltrating NK cells in head and …

Background SARS-coronavirus-2 enters host cells through binding of the Spike protein to
ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess …

Purpose: High numbers of tumor-infiltrating lymphocytes (TIL) are linked to better survival in
patients with cancer. Tissue-resident memory T cells (TRM; CD8+ CD103+) are recognized …