This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Mechanical forces influence different cell types in our bodies. Among the earliest forces
experienced in mammals is blood movement in the vascular system. Blood flow starts at the …

Activation of mechanosensitive ion channels by physical force underlies many physiological
processes including the sensation of touch, hearing and pain,,,,. TRAAK (also known as …

TRAAK channels, members of the two–pore domain K+ (potassium ion) channel family K2P,
are expressed almost exclusively in the nervous system and control the resting membrane …

The volume-regulated anion channel (VRAC) is activated when a cell swells, and it plays a
central role in maintaining cell volume in response to osmotic challenges. SWELL1 …

Of Aristotle's five senses, we know that sight, smell and much of taste are initiated by ligands
binding to G-protein-coupled receptors; however, the mechanical sensations of touch and …

Monday, February 19, 2018 303a neuronal excitability, respond to lipids, temperature and
mechanical stretch, and influence pain, temperature perception and anaesthetic responses …

Two-pore domain (K2P) K+ channels are major regulators of excitability that endow cells
with an outwardly rectifying background" leak" conductance. In some K2P channels, strong …