Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

Many chronic pulmonary diseases are associated with pulmonary hypertension (PH) and
pulmonary vascular remodeling, which is a term that continues to be used to describe a wide …

Abstract Background Mesenchymal stem cells (MSCs) are promising tools for the treatment
of human lung disease and other pathologies relevant to newborn medicine. Recent studies …

Rationale: Chronic hypoxia induces pulmonary vascular remodeling, pulmonary
hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms …

Clinical trials have failed to demonstrate an effective preventative or therapeutic strategy for
bronchopulmonary dysplasia (BPD), a multifactorial chronic lung disease in preterm infants …

The combination of a vascular endothelial growth factor receptor antagonist, Sugen 5416
(SU5416), and chronic hypoxia is known to cause pronounced pulmonary hypertension …

We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung
inflammation and remodeling in experimental emphysema would differ according to MSC …

Hypoxia-induced pulmonary hypertension (PH) is one of the most common and deadliest
forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients …

Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher
Ca2+ levels in pulmonary hypertension (PH). Whether the functional properties and …

Background—Induction of cellular senescence through activation of the p53 tumor
suppressor protein is a new option for treating proliferative disorders. Nutlins prevent the …