BACKGROUND Historical accounts linking cancer and microbes date as early as four
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …

The functional diversity of the mammalian intestinal microbiome far exceeds that of the host
organism, and microbial genes contribute substantially to the well-being of the host …

The human microbiome is an integral component of the human body and a co-determinant
of several health conditions,. However, the extent to which interpersonal relations shape the …

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …

Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

The fine line between human health and disease can be driven by the interplay between
host and microbial factors. This “metagenome” regulates cancer initiation, progression, and …

The intestinal microbiota plays a crucial role in influencing the development of host
immunity, and in turn the immune system also acts to regulate the microbiota through …

Summary Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the
destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In …

Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of
myosin heavy chain 6–specific T helper (TH) 1 and TH17 cells. However, mechanisms …

Little is known regarding differences in the gut microbiomes of rheumatoid arthritis (RA)
patients and healthy cohorts in China. This study aimed to identify differences in the fecal …