Synthetic biology is the repurposing of biological systems for novel objectives and
applications. Through the co-ordinated and balanced expression of genes, both native and …

The field of synthetic biology is evolving at a fast pace. It is advancing beyond single‐gene
alterations in single hosts to the logical design of complex circuits and the development of …

Despite recent progress on synthetic transcription factor generation in eukaryotes, there
remains a need for high-activity bacterial versions of these systems. In synthetic biology …

Bacterial promoters are usually formed by multiple cis-regulatory elements recognized by a
plethora of transcriptional factors (TFs). From those, global regulators are key elements …

Bacteria are a source of a large number of secondary metabolites with several biomedical
and biotechnological applications. In recent years, there has been tremendous progress in …

Here, we investigated novel interactions of three global regulators of the network that
controls biofilm formation in the model bacterium Escherichia coli using computational …

Dense arrangements of binding sites within nucleotide sequences can collectively influence
downstream transcription rates or initiate biomolecular interactions. For example, natural …

Regulation of gene expression in bacteria results from the interplay between hundreds of
transcriptional factors (TFs) at target promoters. However, how the arrangement of binding …

Synthetic biology (SynBio) is a rapidly advancing multidisciplinary field in which South
American countries such as Chile, Argentina, and Brazil have made notable contributions …

The engineering of synthetic circuits in cells relies on the use of well‐characterized
biological parts that would perform predicted functions under the situation considered, and …