The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

FA Harding, MM Stickler, J Razo, R DuBridge - MAbs, 2010 - Taylor & Francis
Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for
their targets, convey effector functions and enjoy robust manufacturing procedures …

Role of hsp90 in systemic lupus erythematosus and its clinical relevance

HD Shukla, PM Pitha - Autoimmune diseases, 2012 - Wiley Online Library
Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved
proteins which play an essential role as molecular chaperones in protein folding and …

Koebner phenomenon in lupus erythematosus with special consideration of clinical findings

H Ueki - Autoimmunity reviews, 2005 - Elsevier
The isomorphic response of Koebner can be observed not only in psoriasis, but also in other
diseases, such as lichen planus and some systemic diseases including LE (lupus …

Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis

B Dema, C Pellefigues, S Hasni, N Gault, C Jiang… - PloS one, 2014 - journals.plos.org
The presence of autoantibodies in systemic lupus erythematosus, particularly those of the
IgG subclass, have long been associated with disease onset and activity. Here we explored …

Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates

B Cauwe, E Martens, P Proost… - Integrative …, 2009 - academic.oup.com
The action radius of matrix metalloproteinases or MMPs is not restricted to massive
extracellular matrix (ECM) degradation, it extends to the proteolysis of numerous secreted …

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

SK Shimp, CB Chafin, NL Regna… - Cellular & molecular …, 2012 - nature.com
Elevated expression of heat shock protein 90 (HSP90) has been found in kidneys and
serum of systemic lupus erythematosus (SLE) patients and MRL/Mp-Fas lpr/Fas lpr …

Toxoplasma gondii infection inhibits the development of lupus‐like syndrome in autoimmune (New Zealand Black × New Zealand White) F1 mice

M Chen, F Aosai, K Norose, HS Mun… - International …, 2004 - academic.oup.com
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
presence of autoantibodies and lupus nephritis. In the present study using New Zealand …

An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients

CI Vidal, PJ Mintz, K Lu, LM Ellis, L Manenti, R Giavazzi… - Oncogene, 2004 - nature.com
To gain insight into the mechanisms of molecular recognition and humoral immune
response in ovarian cancer, we used fingerprinting, a phage display-based combinatorial …

Heat shock proteins in the kidney

R Sreedharan, SK Van Why - Pediatric nephrology, 2016 - Springer
Heat shock proteins (Hsps) are essential to cell survival through their function as protein
chaperones. The role they play in kidney health and disease is varied. Hsp induction may be …

Interplay between the Chaperone System and Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus Pathogenesis: Is Molecular Mimicry the Missing Link …

AM Vitale, L Paladino, C Caruso Bavisotto… - International Journal of …, 2024 - mdpi.com
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized
by self-immune tolerance breakdown and the production of autoantibodies, causing the …