The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …

Isatoic anhydride has attracted a great deal of attention in recent decades. A review of the
methods of preparation of all known quinazoline and quinazolinone derivatives is given …

In this work, ruthenium (II)-catalyzed C–C/C–N annulation of 2-arylquinazolinones with
vinylene carbonate is reported to synthesize fused quinazolinones. This catalytic system …

The DNA-encoded library (DEL) is a powerful hit-generation tool in drug discovery. This
study describes a new DEL with a privileged scaffold quinazolin-4 (3 H)-one developed by a …

Described herein is the development of Ir (III)-catalyzed direct C–H amidation using
azidoformates as a readily deprotectable amino source. Substrates with unactivated methyl …

Tetrahydroquinazoline (THQ) was designed as an all-nitrogen analogue of main-stream
benzoxazine monomers. THQ solutions in DMF gelled at 100° C via HCl-catalyzed ring …

Rutaecarpine is a pentacyclic indolopyridoquinazolinone alkaloid found in Evodia
rutaecarpa and other related herbs. It has a variety of intriguing biological properties, which …

An efficient TFA/TBHP-promoted oxidative cyclisation of readily available isatins with 1, 2, 3,
4-tetrahydroisoquinolines has been firstly developed. This protocol features simple …

A microwave-assisted method for the palladium-catalyzed direct arylation of quinazolin-4-
one has been developed under copper-assistance. This method is applicable to a wide …

MicroRNA (miRNA) maturation is critically dependent on structural features of primary
transcripts (pri-miRNAs). However, the scarcity of determined pri-miRNA structures has …