Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Signaling pathways regulated by mutant Fms-like tyrosine kinase 3 (FLT3)–internal tandem
duplication (ITD), which mediate resistance to acute myeloid leukemia (AML) cell death, are …

Simple Summary Sphingolipids are membrane-associated lipids that are involved in signal
transduction pathways regulating cell death, growth, and migration. In cancer cells …

Ceramide, a bioactive sphingolipid, is now at the forefront of cancer research. Classically,
ceramide is thought to induce death, growth inhibition, and senescence in cancer cells …

Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells.
Their products, ceramides (Cer), are components of cellular membranes but also mediate …

Papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a newly identified non-
coding RNA, which is highly thyroid-specific. Dramatic downregulation in thyroid cancers …

Mechanisms by which cancer cells communicate with the host organism to regulate lung
colonization/metastasis are unclear. We show that this communication occurs via …

Objective Deficiency or reduced expression of signal transduction and activation of RNA
family protein Quaking (Qki) is associated with developmental defects in neural and vascular …