Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

Rho GTPases comprise a family of molecular switches that control signal transduction
pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes …

There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

Rho GTPases impact a number of activities important for oncogenesis. We describe a small
molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in …

Growing evidence indicates that microRNAs have a significant role in tumor development
and may constitute robust biomarkers for cancer diagnosis and prognosis. In this study, we …

Cancer is a disease in which many of the characteristics of normal cell behavior are lost or
perturbed. Uncontrolled cell proliferation and inappropriate cell survival are common …

In vitro and in vivo studies and evidence from human tumors have long implicated Rho
GTPase signaling in the formation and dissemination of a range of cancers. Recently next …

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is an aggressive malignancy; its
mechanisms of development and progression are poorly understood. We used an …

Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …