Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …

For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Retinoids play an important role in development, differentiation, and homeostasis. The
discovery of retinoid receptors belonging to the superfamily of nuclear ligand‐activated …

Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors
that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A …

We have identified a new retinoid response pathway through which 9-cis retinoic acid
(9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear …

The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta
(or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome …

This review addresses recent developments regarding the peroxisome proliferator activated
receptors (PPARs). We will briefly review the older literature regarding the phenomenon of …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals
a previously undiscovered fold of an antiparallel α-helical sandwich, packed as dimeric …