Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …

Liver pathological changes are as high as 21%-78% in diabetic patients, and treatment
options are lacking. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor that is widely …

The gastrointestinal tract stores ingested nutrients in the stomach which are then delivered
to the small intestine at a controlled rate to optimize their digestion and absorption. The …

Intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1),
cholecystokinin and insulin; slows gastric emptying (GE); and lowers post-meal glucose in …

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the
targets for many different classes of pharmacotherapy. The islets of Langerhans are central …

Glucagon-like peptide 1 (GLP-1) is a multifaceted intestinal hormone with diverse
physiological functions throughout the body. Previously, we demonstrated that the steviol …

Polyphenols are phytochemical compounds found mostly in plants with several biological
properties. Many of the benefits attributed to fruits and vegetables have been linked to their …

Introduction: Metformin is established as the first-line therapy for type 2 diabetes (T2DM), but
its mode of action remains elusive. Elucidation of the mechanisms underlying the anti …

In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate
endocrine, behavioral, and immunological responses. T2R agonists include indicators of …