Current concepts in meniscus tissue engineering and repair

B Bilgen, CT Jayasuriya… - Advanced healthcare …, 2018 - Wiley Online Library
The meniscus is the most commonly injured structure in the human knee. Meniscus
deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal …

Mesenchymal stem cells from different sources in meniscus repair and regeneration

G Ding, J Du, X Hu, Y Ao - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Meniscus damage is a common trauma that often arises from sports injuries or menisci
tissue degeneration. Current treatment methods focus on the repair, replacement, and …

Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration

H Sun, X Wen, H Li, P Wu, M Gu, X Zhao… - Annals of the …, 2020 - ard.bmj.com
Objectives The heterogeneity of meniscus cells and the mechanism of meniscus
degeneration is not well understood. Here, single-cell RNA sequencing (scRNA-seq) was …

Engineering anisotropic meniscus: zonal functionality and spatiotemporal drug delivery

A Abbadessa, J Crecente-Campo… - Tissue Engineering Part …, 2021 - liebertpub.com
Human meniscus is a fibrocartilaginous structure that is crucial for an adequate performance
of the human knee joint. Degeneration of the meniscus is often followed by partial or total …

Cell‐free strategies for repair and regeneration of meniscus injuries through the recruitment of endogenous stem/progenitor cells

W Guo, W Xu, Z Wang, M Chen, C Hao… - Stem Cells …, 2018 - Wiley Online Library
The meniscus plays a vital role in protecting the articular cartilage of the knee joint. The
inner two‐thirds of the meniscus are avascular, and injuries to this region often fail to heal …

Hydrogels for precision meniscus tissue engineering: a comprehensive review

A Rey-Rico, M Cucchiarini, H Madry - Connective tissue research, 2017 - Taylor & Francis
The meniscus plays a pivotal role to preserve the knee joint homeostasis. Lesions to the
meniscus are frequent, have a reduced ability to heal, and may induce tibiofemoral …

Advanced polymer-based drug delivery strategies for meniscal regeneration

H Li, Z Yang, L Fu, Z Yuan, C Gao, X Sui… - … Engineering Part B …, 2021 - liebertpub.com
The meniscus plays a critical role in maintaining knee joint homeostasis. Injuries to the
meniscus, especially considering the limited self-healing capacity of the avascular region …

Advances in the mechanisms affecting meniscal avascular zone repair and therapies

W Yan, W Dai, J Cheng, Y Fan, T Wu, F Zhao… - Frontiers in Cell and …, 2021 - frontiersin.org
Injuries to menisci are the most common disease among knee joint-related morbidities and
cover a widespread population ranging from children and the general population to the old …

Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D …

A Rey-Rico, A Klich, M Cucchiarini, H Madry - Scientific reports, 2016 - nature.com
Alginates are important hydrogels for meniscus tissue engineering as they support the
meniscal fibrochondrocyte phenotype and proteoglycan production, the extracellular matrix …

Angiogenic approaches to meniscal healing

LB Williams, AB Adesida - Injury, 2018 - Elsevier
Meniscal injuries commonly result in osteoarthritis causing long term morbidity, lifelong
treatment, joint replacement and significant financial burden to the Canadian healthcare …