A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing

X Liu, J Meng, X Liao, Y Liu, Q Zhou, Z Xu… - Cellular & Molecular …, 2023 - nature.com
Abstract Vogt–Koyanagi–Harada (VKH) disease is a leading cause of blindness in young
and middle-aged people. However, the etiology of VKH disease remains unclear. Here, we …

[HTML][HTML] ASF1b is a novel prognostic predictor associated with cell cycle signaling pathway in gastric cancer

C Chen, H Bao, W Lin, X Chen, Y Huang… - Journal of …, 2022 - ncbi.nlm.nih.gov
Gastric cancer (GC) is one of the most common malignant tumors with poor outcomes.
Identification of new therapeutic targets is urgently needed. Accumulating evidence has …

Exploring the molecular characteristics of the malignant potential of gastric adenocarcinoma with enteroblastic differentiation

Y Wang, X Wei, B Ke, J Liu, Y Guo, Y Liu… - …, 2023 - Wiley Online Library
Aims Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare subset of
alpha‐fetoprotein (AFP)‐producing carcinomas with poor prognosis. However, the …

Single‐cell characteristics and malignancy regulation of alpha‐fetoprotein‐producing gastric cancer

Y Mei, M Li, J Wen, X Kong, J Li - Cancer Medicine, 2023 - Wiley Online Library
Objective To characterize alpha‐fetoprotein (AFP)‐producing gastric cancer (AFPGC) at the
single‐cell level and to identify regulatory factors for AFP expression and malignancy …

Both the serum AFP test and AFP/GPC3/SALL4 immunohistochemistry are beneficial for predicting the prognosis of gastric adenocarcinoma

B Wang, Y Xie, L Zheng, X Zheng, J Gao, X Liu… - BMC …, 2021 - Springer
Background Both gastric adenocarcinoma with primitive enterocyte phenotype
(GAPEP)(including hepatoid adenocarcinoma) and alpha-fetoprotein (AFP)-producing …

Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment

P Yu, C Hu, G Ding, X Shi, J Xu, Y Cao, X Chen… - Nature …, 2024 - nature.com
Ovarian metastasis is one of the major causes of treatment failure in patients with gastric
cancer (GC). However, the genomic characteristics of ovarian metastasis in GC remain …

Patient-derived xenograft models for gastrointestinal tumors: A single-center retrospective study

X Yu, Y Chen, J Lu, K He, Y Chen, Y Ding, K Jin… - Frontiers in …, 2022 - frontiersin.org
Background Patient-derived xenograft (PDX) models have shown a great efficiency in
preclinical and translational applications. Gastrointestinal (GI) tumors have a strong …

The epigenetic modifier lysine methyltransferase 2C is frequently mutated in gastric remnant carcinoma

B Sun, H Chen, J Lao, C Tan, Y Zhang… - The Journal of …, 2023 - Wiley Online Library
Gastric remnant carcinoma (GRC), which occurs in the stomach after partial gastrectomy, is
a rare and aggressive form of gastric adenocarcinoma (GAC). Comprehensive profiling of …

Chromosome instability region analysis and identification of the driver genes of the epithelial ovarian cancer cell lines A2780 and SKOV3

J Li, Z Chen, W Xiao, H Liang, Y Liu… - Journal of Cellular …, 2023 - Wiley Online Library
Epithelial ovarian cancer (EOC) is one of the most prevalent gynaecological cancers
worldwide. The molecular mechanisms of serous ovarian cancer (SOC) remain unclear and …

[HTML][HTML] Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach

M Zhu, E Chen, S Yu, C Xu, Y Yu, X Cao… - Cancer …, 2022 - ncbi.nlm.nih.gov
Dear Editor, Hepatoid adenocarcinoma (HAC) is a rare pathological subtype of extrahepatic
tumor, featured by hepatoid differentiation and α-fetoprotein (AFP)-production [1, 2] …