G protein-coupled receptors are the target of more than 30% of all FDA-approved drug
therapies. Though the purinergic P2 receptors have been an attractive target for therapeutic …

Gliomas are the most common malignant brain tumors in adults, characterized by a high
proliferation and invasion. The tumor microenvironment is rich in growth-promoting signals …

Gastric cancer (GC) is a major health concern worldwide, presenting a complex
pathophysiology that has hindered many therapeutic efforts so far. In this context, purinergic …

Prostate cancer (PC) is the most diagnosed tumor in males and ranks as the second leading
cause of male mortality in the western world. The CD39 and CD73 enzymes play a crucial …

MTHFD1L, a key enzyme of folate metabolism, is seldom reported in cancer. In this study,
we investigate the role of MTHFD1L in the tumorigenicity of esophageal squamous cell …

Purpose It is well known that inflammation plays a key role in complex pathological
progressions of alcohol-associated liver disease (ALD). To date, effective therapy for ALD is …

Background P2Y receptors are a family of G protein-coupled receptor genes that have an
important function in cancer development and metastasis. However, systematic studies have …

Glioblastoma (GBM) is the most aggressive and lethal among the primary brain tumors, with
a low survival rate and resistance to radio and chemotherapy. The P2Y12 is an adenosine …

Esophageal squamous cell carcinoma (ESCC) is one of the subtypes of esophageal cancer
with Chinese characteristics, and its five‐year survival rate is less than 20%. Early diagnosis …

Our previous work had identified that at the acupuncture point (acupoint), acupuncture-
induced ATP release was a pivotal event in the initiation of analgesia. We aimed to further …