Mechanochemistry: new tools to navigate the uncharted territory of “impossible” reactions

F Cuccu, L De Luca, F Delogu, E Colacino… - …, 2022 - Wiley Online Library
Mechanochemical transformations have made chemists enter unknown territories, forcing a
different chemistry perspective. While questioning or revisiting familiar concepts belonging …

Mechanochemistry for synthesis

T Friščić, C Mottillo, HM Titi - Angewandte Chemie, 2020 - Wiley Online Library
Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical
action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers …

Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

JL Howard, Q Cao, DL Browne - Chemical science, 2018 - pubs.rsc.org
Mechanochemistry is becoming more widespread as a technique for molecular synthesis
with new mechanochemical reactions being discovered at increasing frequency. Whilst …

A guide to direct mechanocatalysis

S Hwang, S Grätz, L Borchardt - Chemical Communications, 2022 - pubs.rsc.org
Direct mechanocatalysis (DM) describes solvent-free catalytic reactions that are initiated by
mechanical forces in mechanochemical reactors such as ball mills. The distinctive feature of …

Mechanochemistry: a force of synthesis

JL Do, T Friščić - ACS central science, 2017 - ACS Publications
The past decade has seen a reawakening of solid-state approaches to chemical synthesis,
driven by the search for new, cleaner synthetic methodologies. Mechanochemistry, ie …

Altering product selectivity by mechanochemistry

JG Hernández, C Bolm - The Journal of organic chemistry, 2017 - ACS Publications
Mechanochemical activation achieved by grinding, shearing, pulling, or milling opens
unique opportunities in synthetic organic chemistry. Common features are that …

Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)

D Tan, L Loots, T Friščić - Chemical Communications, 2016 - pubs.rsc.org
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Advances in organometallic synthesis with mechanochemical methods

NR Rightmire, TP Hanusa - Dalton Transactions, 2016 - pubs.rsc.org
Solvent-based syntheses have long been normative in all areas of chemistry, although
mechanochemical methods (specifically grinding and milling) have been used to good effect …

Mechanochemical and mechanoenzymatic synthesis of pharmacologically active compounds: A green perspective

M Pérez-Venegas, E Juaristi - ACS Sustainable Chemistry & …, 2020 - ACS Publications
Recently, the application of mechanochemical strategies in organic synthesis has attracted
the attention of both the academic and industrial chemical communities. The high efficiency …