The kidney plays a fundamental role in maintaining body salt and fluid balance and blood
pressure homeostasis through the actions of its proximal and distal tubular segments of …

One-hundred years ago, Starling articulated the interdependence of renal control of
circulating blood volume and effective cardiac performance. During the past 25 years, the …

Cell senescence plays a key role in age-associated organ dysfunction, but the in vivo
pathogenesis is largely unclear. Here, we generated a p16-Cre ERT2-tdTomato mouse …

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause
of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs …

Abstract The Na+, K+-ATPase (NKA) is an ubiquitous enzyme consisting of α, β and γ
subunits, and is responsible for the creation and maintenance of the Na+ and K+ gradients …

The central goal of this overview article is to summarize recent findings in renal epithelial
transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct …

Metabolic syndrome (MetS), a complex of interrelated risk factors for cardiovascular disease
and diabetes, is comprised of central obesity (increased waist circumference) …

All components of the renin angiotensin system necessary for ANG II generation and action
have been reported to be present in renal proximal convoluted tubules. Given the close …

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have clearly demonstrated their
beneficial effect in diabetic kidney disease (DKD) on top of the standard of care [blood …

Arterial hypertension (AHT) currently affects approximately 40% of adults worldwide, and its
pathological mechanisms are mainly related to renal, vascular, and endocrine systems …