Bisimine derivatives of salicylaldehyde with chiral diamines (salens) are privileged ligands
in asymmetric organometallic catalysis, which can be used in cooperation with …

The addition of cyanide to a carbonyl compound to form a cyanohydrin is one of the
fundamental carbon-carbon bond forming reactions in organic chemistry1 and has …

Catalytic asymmetric cyanations of prochiral unsaturated compounds affording the
corresponding nitrile products in high enantiomeric excess (≥ 90% in general) are …

Asymmetry is ubiquitous in every part of Nature1 and has a great impact in many fields, not
only in chemistry but also even in arts. In the pharmaceutical area, asymmetry plays an …

The mechanism of the enantioselective cyanosilylation of ketones catalyzed by tertiary
amino-thiourea derivatives was investigated using a combination of experimental and …

Chiral cyanohydrins are versatile building blocks for pharmaceuticals, agrochemicals and
specialty materials. A number of efficient and successful synthetic methods have been …

Two‐in‐one: The integration of two salen/Ti O units into one molecule allows the
enantioselective cyanation of aldehydes to afford the enantioenriched natural or nonnatural …

A highly enantioselective cyanohydrin synthesis with aromatic aldehydes using chiral lithium
binaphtholate aqua or alcohol complexes has been developed and is a simple and …

Full investigation of cyanation of aldehydes, ketones, aldimines and ketimines with
trimethylsilyl cyanide (TMSCN) or ethyl cyanoformate (CNCOOEt) as the cyanide source has …

Carboxylic acids are valued synthetic building blocks that offer shelf life stability, structural
diversity, and wide commercial availability. Despite the remarkable synthetic utility of …